Bacillus anthracis, commonly known as anthrax, is extremely efficient at injecting its toxin into host cells. This characteristic is part of the reason that live Bacillus anthracis is handled at high biosafety levels in the laboratory. But it also prompted researchers at MIT to consider ways to use anthrax’s efficient delivery method to their advantage. The result? A new potential drug delivery method for cancer treatments!
Antibody mimics can disrupt protein interactions inside cells- including cancer-causing proteins. But getting them there is the challenge. Researchers used a component of the anthrax toxin to carry them. But this time, instead of injecting anthrax toxin into cells, the antibody mimics were injected. And it worked! The next step in this research is to attempt to translate it into animal models. Hopefully, this research will move forward and prove to be successful enough in animals to start human clinical trials! Read about it here.
This isn’t the first time researchers have used the Trojan horse approach in disease treatment research. Read about a similar method used in Alzheimer’s research here.