Bone marrow is a complex tissue that, until now, could only be studied in living animals. Recently, Harvard researchers created “bone marrow on a chip” by reproducing the structure and function of bone marrow. Past efforts involving combining cells on an artificial surface have failed, because bone marrow is extremely complex. So researchers turned to animals for help. By creating a framework of bone powder and implanting it under the skin of an animal, the animal’s body did the work for them and created an impressive bone and marrow structure!
The engineered bone marrow could help researchers assess potential side effects of cancer treatments, observe the effects of drugs to prevent radiation poisoning, and even generate blood cells. It may even be possible to grow human bone marrow in immune-deficient mice!
Researchers work with animals because they often give more accurate information than cell cultures and computer simulations alone. From vaccine development to cancer treatments to joint replacement surgery, animals have been- and continue to be- extremely important in the effort to save lives. And now, animals are helping researchers create better alternatives, which could ultimately reduce the number of animals needed in research without compromising research outcomes. Good news for everyone!
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