Researchers at the Institute for Research in Immunology and Cancer (IRIC) in Montreal have identified a key gene (called Brg1) that regulates leukemia stem cells. What’s more- they’ve figured out a way to disarm it!
This isn’t an easy thing to figure out. Sometimes, when cancer cells are targeted, normal cells are also damaged because the genes involved in regulating cancer cells may also be essential in normal cell function. They need to know exactly what the gene does in order to figure out what they can- and can’t- do with it.
But how do they figure this out? You certainly wouldn’t want to try to shut down a gene in a human patient without fully understanding what you’re doing. This is a great example of the importance of animal-based research. Cell cultures can definitely tell you a lot, but when you want to find out how a treatment is going to affect an entire living system, animals are truly life-savers.
And based on animal and cell studies, it looks like normal blood cells don’t need Brg1 to function! More work is needed before moving into clinical trials, but this could definitely be life-changing. The cancer stem cells that Brg1 regulates are more resistant to treatments, and the ability to turn them off could make treating leukemia easier and also help prevent relapses without damaging normal cells!
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