New understanding of Alzheimer’s Disease for 2014!

Toward Digital EncryptionResearchers at Columbia University Medical Center have unlocked several important pieces of information about Alzheimer’s Disease: exactly where it starts, why it starts there, and how the disease spreads.

They’ve identified the specific part of the brain where Alzheimer’s starts- the lateral entorhinal cortex (LEC). The LEC normally accumulates tau, which makes it more likely to accumulate a specific protein called APP- and the combination of tau and APP damages neurons. Not good. 

And Alzheimer’s spreads like a domino effect. When neurons are compromised in the LEC, the neurons in surrounding areas also become compromised- including the hippocampus, which plays an important role in long-term memory storage.

Researchers used fMRI imaging and worked with humans and mice to discover this information. By showing that early changes can be detected using fMRI- and knowing exactly how the process works- detecting the disease before it spreads could be much easier. And this new imaging method could be a very helpful way to determine effectiveness of potential drugs! Read more here:

http://newsroom.cumc.columbia.edu/blog/2013/12/22/how-alzheimers-spreads/?utm_source=rss&utm_medium=rss&utm_campaign=how-alzheimers-spreads

2 thoughts on “New understanding of Alzheimer’s Disease for 2014!

  1. Stephen in Alabama

    Those researchers at the Columbia Medical Center deserve a lot of praise for these discoveries. I am incredibly impressed by the work they have done. The tragic effects of this terrible disease have affected me personally and I hold out hope that we will be able to develop better treatments and methods of prevention in the very near future.

    1. Science Kicks Ass Post author

      Absolutely! And if you have the time, make sure to thank them directly by responding to their article! I, too, have unfortunately dealt with family members with Alzheimer’s, and in my opinion, we should keep an eye on research advances in the prevention of the disease- there’s some exciting work going on! As I am particularly interested in developments in Alzheimer’s, I often write about current research studies on the disease- stay tuned! And thanks for your interest!

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