In a novel approach at preserving fertility, researchers have successfully produced live offspring from cryopreserved testicle tissue.
You may think that cryopreserving testicle tissue is kind of a stretch- but many cancer patients undergoing treatments don’t have options when it comes to preserving fertility. Doctors can cryopreserve sperm if the patient has already reached puberty, but for young boys, that’s not an option.
By cryopreserving testicle tissue, researchers are able to thaw tissue at a later date and induce the production of sperm. This research was carried out in mice, and through artificial insemination, eight healthy offspring were produced! Amazingly, thawed tissue was able to produce sperm just as well as unfrozen tissue.
There’s still some work to be done before this research can be translated into humans. But as more and more pediatric cancer patients are being successfully cured of their diseases, this research could mean life-changing, long-term fertility options. Read more about it here:
Is it possible that a woman’s fertility is affected by her perception of the safety of her environment? Researchers are trying to figure out how to answer this question, and you’re not going to believe which tiny animals are helping them. Roundworms!
Roundworms reproduce by themselves by carrying around their own sperm AND eggs. And it turns out that when the worm’s environment is favorable (enough nutrition, not too much competition), they reproduce better. A chemical trail from the worm’s nose to its ovaries ramps up production of prostaglandins, which help guide the sperm to the eggs.
Roundworms are a good model for this type of research, because the worm’s skin is transparent, so sperm motility is easy to observe. Now, researchers are expanding on these studies by looking at prostaglandin levels in human patients to see if they’re correlated with fertility. But the thought that smell and the perception of the environment could alter fertility is interesting, and it could possibly lead to therapies that could help humans and animals with fertility problems!
Research in these worms indicates that the production of prostaglandins might be possible in more ways than previously thought, and in addition to possibly answering some questions about fertility, roundworms might be able to give researchers insight into different targets for pain management and cancer treatments. Read more about it here: