The day before surgery, a patient would be injected with nanoprobes that migrate to the tumor cells. These nanoprobes don’t affect normal brain tissue. Then, during surgery, the surgeon would use a device that detects these nanoprobes to determine whether they had successfully removed all of the malignant cells. The device looks like a laser pointer, and in laboratory studies with mouse models of human GBM, researchers were able to remove all of the malignant cells from the mice!
This may be ready for human clinical trials relatively quickly, and it’s possible that it could be helpful in the treatment of other types of brain cancer as well. Read more about it here:
Glioblastoma is an aggressive form of brain cancer that can be difficult to treat. The tumors are often located in inaccessible areas, making surgery impossible. So researchers in Atlanta got creative and figured out a way to make the cancer cells more accessible. And their technique is not unlike the concept of a mouse trap- but for this one, rats helped figure it out!
Glioblastoma cells migrate along nerves and blood vessels. And researchers used that information to their advantage by creating a small rod that mimics the shape of these nerves and blood vessels. Through animal studies in rats, they’ve shown that the cancer cells then ‘take the bait’ and migrate along this rod. At the end of the rod, the cells are met with a cancer-killing drug. So instead of delivering drugs to the tumor, the tumor comes to the drug!
This could make a huge difference for patients with inoperable tumors. Not only could this cancer cell “mouse trap” lure cells into an area that would be easier for doctors to access, but it could also work by shrinking slow-growing tumors to the point where they wouldn’t be able to do as much damage. Let’s hope that this treatment makes its way into human trials quickly!