Tag Archives: Karolinska

Hearing loss linked to a clock!

iStock_000014889492SmallDon’t worry, your alarm clock probably isn’t causing hearing loss. Well, at least not during the day! Let me explain. You probably know that your sleep patterns, hormone levels, body temperature, and immune system are affected by circadian rhythms, which are controlled by biological clocks. Circadian rhythms have also been linked to obesity, diabetes, heart disease, metabolism, and depression- and new research shows a potential link to hearing loss.

Researchers at the Karolinsksa Institutet in Stockholm have discovered that there is a biological clock in the ear, controlled by genes that regulate circadian rhythms. Through research in mice, they found that higher noise levels during the night resulted in permanent hearing damage, but the same noise levels during the day didn’t affect their hearing.

There is a growth hormone (called BDNF) that protects auditory nerve cells. These levels fluctuate through the day, regulated by your ‘ear clock.’ BDNF levels were lower at night, so the mice were more prone to hearing damage. But by stimulating BDNF levels at night, researchers were able to protect hearing during noise exposure!

This is an important discovery. Many people work in professions that expose them to higher noise levels at night, and understanding the mechanisms behind protecting hearing could help researchers develop new treatments for hearing loss. Read more about it here:

http://news.cision.com/karolinska-institutet/r/new-discovery-paves-the-way-for-medicine-for-people-with-hearing-disabilities,c9540948

Exploding cancer cells? Yes, please!

iStock_000006862055SmallGlioblastoma is an aggressive type of brain tumor. Glioblastomas are difficult to treat, very aggressive, and survival rates aren’t very good. But researchers at Karolinska Institutet in Stockholm have found a potential silver bullet- a substance called Vacquinol-1 that makes glioblastoma cells explode and die!

So how does it work? This molecule alters the cancer cells so they can’t control the substances being carried into the cell from the outside. This results in a large number of vacuoles forming inside the cell, and eventually, the cell explodes.

To develop this treatment, researchers used cell cultures and exposed tumor cells to different molecules. Once they found molecules that killed the tumor cells, they did more research to narrow down potential candidates for a treatment. They identified a single molecule that they wanted to pursue, and through further studies in mice, they found that tumor growth was reversed and the mice survived for longer than those in control groups.

This could potentially work on other types of cancer cells, too, but until clinical trials proceed, researchers won’t know. The hope is to get this treatment into clinical trials quickly, because this is definitely a novel approach to attacking this type of tumor! Read more:

http://www.laboratoryequipment.com/news/2014/03/substance-makes-cancer-explode?et_cid=3836544&et_rid=655142386&type=cta