Tag Archives: liver

Liver transplant availability improved by rats

iStock_000015700850SmallLiver transplants may soon become available to many more patients, thanks to a slow-cooling method that  was developed in rats. This technique could make over 5,000 extra organs available to patients each year. Currently, a human liver only lasts for about 12 hours, so the pool of transplant recipients is very limited and depends on the patient’s proximity to the donor hospital.

Freezing organs can cause ice crystals, which can damage the cells. This slow-cooling method prevents the formation of ice crystals by introducing a chemical that protects the cells. The liver can then be stored at -6 degrees Celsius before it’s warmed back to body temperature and transplanted. Researchers also believe it’s possible to use this method on larger organs.

Pretty amazing- and this could mean the difference between life and death for thousands of patients! Between this cooling method and other advances aimed at organ preservation during transport, humans could likely begin to see the benefits of this research rather quickly. In this instance, the chemical components of this technique are already approved for use in humans, so after further research in larger animals, human trials won’t be far behind.

http://www.nature.com/news/supercooled-livers-last-for-days-1.15465

Don’t look now- but organ transplants are about to be REVOLUTIONIZED!

iStock_000021023060SmallOn average, a heart or a lung kept on ice will only last about 6 hours outside of the body. The organs suffer some damage during this time, so the chances of transplant success decrease as time passes. This severely limits the ability for a recipient to be able to receive donor organs- a team needs to be able to deliver the organ to the recipient’s location in a relatively short period of time, so it’s impossible for a patient in New York to receive a heart from a donor in Hawaii. And unfortunately, desperately needed donor organs are sometimes wasted because there are no potential recipients within range to accept them. 

But that may be about to change. Meet TransMedics’s Organ Care System. This amazing machine can pump oxygenated blood through hearts, lungs, livers and kidneys- AND monitor their performance! This could potentially increase the window of opportunity for recipients by keeping organs viable for longer periods of time, and improve patient outcomes by giving doctors a better idea of the chances of success for the transplanted organ!

Thanks to animal-based research that started over 100 years ago, the success of long-term tissue grafts and the ability to minimize organ rejection has saved many lives. The limitation was ice; and if study results are positive, the Organ Care System could revolutionize organ transplants!

Watch these videos of a lung and a heart in the machine- it’s amazing!

BPA and cancer: a direct link discovered

Composition with plastic bottles of mineral waterBisphenol A, or BPA, is a chemical that’s found in many of the products we use every day. It’s an endocrine disruptor, so it can interfere with the hormones in your body. It’s used to make many plastics and resins, and you’ll find it in food cans, water bottles, dental fillings, DVDs and CDs, cash register tape, and much more. Previous research has shown that BPA can- and does- leach into food products, but until now, there hasn’t been a direct link established between BPA and cancer. BPA has been linked to plenty of other health issues, though.

Now, new research from the University of Michigan shows a direct link between BPA exposure and liver cancer. Pregnant mice were fed a diet containing human-relevant amounts of BPA during their pregnancy and while they were nursing their pups. And the babies of these mice were much more likely to develop liver tumors than control mice- it seems that the developing pups weren’t able to rid their systems of the chemical as efficiently as adults.

What does this mean for you? Pay attention to food labels! Look for BPA-free products, limit the amount of food you eat from cans and plastic containers that contain BPA, and be especially careful when you’re pregnant and when you have children in the home. Diet and health fads may come and go, but as we learn more about BPA, the news only gets worse. Read about the study here:

http://www.ns.umich.edu/new/multimedia/videos/21951-liver-tumors-found-in-mice-exposed-to-bpa

Third-hand smoke just as dangerous as actually smoking?

Smoking killsFirst-hand smoke exposure is the smoke inhaled by the actual smoker, and second-hand smoke exposure is when others inhale the exhaled smoke. But according to new research, third-hand smoke exposure could be just as dangerous as first- and second-hand smoke.

Third-hand smoke exposure is exposure to surfaces that have been contaminated with second-hand smoke. When a smoker moves out of a house, surfaces and dust can remain contaminated. As time goes on, nicotine is re-emitted from the contamination, and nicotine exposure can approach the levels of first-hand smoking.

Mice exposed to third-hand smoke were hyperactive, experienced significant lung and liver damage, and their wound healing abilities were reduced. In addition to these findings, it was found that third-hand smoke exposure can lead to type II diabetes!

What does this mean for you? Well, it might be more important than you think to choose a hotel that prohibits smoking and pay more attention to the smoking habits of previous owners of your new homes and automobiles. While a lingering odor of smoke might dissipate over time, the lasting effects may not. If you’re still smoking, here’s another great reason to consider the effects you may be having on your kids, your friends’ kids, and those who will be here long after you are.

http://ucrtoday.ucr.edu/20236