With increased breast cancer awareness and the growing number of diagnostic tools available- including MRI, mammograms, and genetic testing- more and more women are diagnosed with precancerous breast tissue. And unnecessary surgery and treatments are becoming more common, because doctors can’t accurately tell which of these women will actually go on to develop cancer.
But instead of using a “better safe than sorry” approach, researchers want to be able to determine which genes drive breast cancer- and stop them! Because the genes in cells work together in complex and sometimes unexplained ways, simply looking at genes that are activated as cancer develops doesn’t always work.
Using a combination of science, mathematics and engineering, researchers pinpointed a gene that had the strongest statistical link to breast cancer (HoxA1) by reverse-engineering gene networks. And by using a novel therapy to block this gene, they were able to reverse cancer cells in culture as well as prevent cancer development in mice! Pretty amazing- check it out!