Adenomyosis is a gynecological disease that can cause infertility and chronic pelvic pain. While there are some medications that can be used to alleviate symptoms, the only definitive treatment for the disease is a hysterectomy. But now, researchers at Michigan State University have created a mouse model that can help researchers understand processes in the disease’s development. This is significant, because most women with the disease require some type of surgery, and a treatment that allows a woman to avoid a hysterectomy would be ideal.
Until now, there hasn’t been a reliable animal model for this disease, and it will be interesting to see how the development of this new mouse model can help researchers discover a cure for adenomyosis. For women suffering with infertility issues due to the disease, this could be life-changing!
According to the CDC, infertility affects approximately 11% of women. That’s over 1 in 10 women that will experience some degree of infertility! There are many causes, and while some women receive a diagnosis (like adenomyosis), others may not. We still have a lot to learn about infertility, but rest assured, researchers are working hard to figure it out.
E. coli showing evolution? Yes! Researchers at Michigan State University have been growing Escherichia coli for 25 years, which is over 58,000 generations, in a project called the Long-Term Experimental Evolution project. And during this time, through studying 12 populations of E. coli, they have found that the bacteria continues to adapt to its environment, with no upper limit in sight- even in the 40,00-50,000 generation range, E. coli‘s “fitness” (a measure of how the organism has adapted to its environment) increased by 3-4% per generation!
Another interesting find: several genetic changes that took place over thousands of generations allowed one of the E. coli colonies to develop the ability to eat the chemical citrate in the presence of oxygen (an ability that E. coli hasn’t had since the Miocene epoch!). Careful record-keeping allowed the researchers to look back at previous generations and track the development of this ability.
Just a fun fact for you- it would take almost two and a half million years to look at 58,000 generations of humans. Bacteria and animals with short lifespans can give us incredible insights into genetic changes that we wouldn’t be able to see in humans.