Tag Archives: relapse

Malaria: Are malaria parasites smarter than we think?

tiger-mosquito-49141_640Smart parasites? It sounds ominous, but new research into malaria parasites is giving scientists a better understanding of disease transmission. It seems that the malaria parasite is able to increase its own transmission rate by ‘relapsing’ during the times that the host animal is bitten by the insects that are capable of spreading it.

Researchers worked with domestic canaries infected with Plasmodium relictum, which is the most common parasite involved in cases of bird malaria in Eastern songbirds. They found that when the canaries were bitten by uninfected mosquitoes, parasite numbers in their blood increased, which in turn resulted in higher infection rates of the mosquitoes.

Pretty efficient. So how can understanding parasite evolution help us? Ultimately, understanding the factors that lead to these ‘relapses’ could help researchers develop better ways to control the disease. While it’s not yet known whether this type of transmission is present in humans, there are many other human pathogens that can also relapse after dormant periods (such as HIV, Herpes Simplex, and Mycobacterium tuburculosis), so it’s possible that this research could help scientists understand potential triggers for relapse in these diseases, as well. Read more about it here:

http://www.sciencedaily.com/releases/2014/09/140911135436.htm

New leukemia treatment might be able to prevent relapses

iStock_000006901657XSmallResearchers at the Institute for Research in Immunology and Cancer (IRIC) in Montreal have identified a key gene (called Brg1) that regulates leukemia stem cells. What’s more- they’ve figured out a way to disarm it!

This isn’t an easy thing to figure out. Sometimes, when cancer cells are targeted, normal cells are also damaged because the genes involved in regulating cancer cells may also be essential in normal cell function. They need to know exactly what the gene does in order to figure out what they can- and can’t- do with it.

But how do they figure this out? You certainly wouldn’t want to try to shut down a gene in a human patient without fully understanding what you’re doing. This is a great example of the importance of animal-based research. Cell cultures can definitely tell you a lot, but when you want to find out how a treatment is going to affect an entire living system, animals are truly life-savers.

And based on animal and cell studies, it looks like normal blood cells don’t need Brg1 to function! More work is needed before moving into clinical trials, but this could definitely be life-changing. The cancer stem cells that Brg1 regulates are more resistant to treatments, and the ability to turn them off could make treating leukemia easier and also help prevent relapses without damaging normal cells!

Read more about this exciting research:

http://www.iric.ca/en/2014/02/a-promising-new-approach-for-treating-leukemia/