For most people, the sight of a spider isn’t cause for good news. Instead, these eight-legged creatures often bring out the worst in people, causing voices to jump up an octave or two. So it may be surprising that a poisonous spider would prompt excitement from anyone other than a dedicated entomologist. But actually, patients with erectile dysfunction may be pretty excited about the prospects of clinical applications for a particular spider’s venom!
The Brazilian Wandering Spider may be the world’s most toxic spider. With a leg-span of up to five inches, and a deadly neurotoxin on board, this spider is definitely one for your nightmares.
If a man is bitten, one side effect can be a painful erection that lasts for hours, potentially causing permanent damage. But researchers investigated further and extracted a particular toxin (PnTx2-6) from the venom. They found that it increases the availability of nitric oxide, which dilates blood vessels and increases blood flow. In rats with erectile dysfunction, researchers saw promising results!
As the toxin works differently than erectile dysfunction drugs that are on the market today, it’s possible that therapies using this toxin could be effective treatments for erectile dysfunction in patients that haven’t responded to conventional therapies. This isn’t the first time scientists have looked towards venomous animals to provide inspiration for human therapies- read more about tarantula and centipede venom as pain medications, and snake venom for cancer treatments and possible treatments for heart disease. It will be interesting to see if spider venom can help human patients with ED- stay tuned for more research!