Tag Archives: T cells

Bone marrow transplant outcomes improved by unlikely sources!

iStock_000008340944SmallHorses and rabbits can help improve outcomes for human patients receiving bone marrow transplants. Wait- horses and rabbits? Yes!

Bone marrow transplants involve harvesting stem cells from the bone marrow of a healthy person and transplanting them into a patient with certain cancers or blood disorders- leukemia, aplastic anemia, and sickle cell disease, to name a few. Harvesting stem cells from a relative usually has the best outcome, but that’s not always possible. A full sibling only has about a 25% chance of being a match, so most patients find an unrelated match through the bone marrow registry. (www.bethematch.org) Finding a way to improve the outcome for unrelated matches is always a goal in research- and this is where horses and rabbits come in!

Researchers inject human T-cells into a rabbit or a horse. Then, the animal’s immune system kills the T-cells and their bodies create antibodies. These antibodies are then removed and given to human patients- and they then kill the patient’s T-cells, reducing the risk of rejection!

Horse or rabbit anti-thymocyte globulin (ATG) has been used to prevent organ rejection in transplant patients as well as in the treatment of aplastic anemia. Talk about animals helping people!

http://www.sciencedaily.com/releases/2012/07/120706234753.htm

Leukemia treatment WORKS on “incurable” patients!

Leukemia medical posterA novel treatment proves successful in patients with INCURABLE cases of leukemia! 59 patients who had exhausted all other treatment options were treated with a new therapy at UPenn. Out of 32 adult patients with chronic lymphocytic leukemia (CLL), 15 responded to the treatment and 7 experienced complete remissions. All of the 5 first adult patients with acute lymphoblastic leukemia (ALL) experienced complete remissions!

But the most amazing results were seen in pediatric cancer patients! Out of 22 patients with ALL, 80% experienced complete remissions! And keep in mind- these were all patients whose cancer was completely resistant to all other types of chemotherapy and who would have died.

Here’s how it works: T-cells are collected from the patient and are then genetically modified so that they target tumor cells. These modified T-cells are then infused back into the patient, where they begin to do their jobs. Because the T-cells are made to target only the proteins expressed on cancer cells, normal cells are left alone. And these T-cells remain in the body, protecting patients from relapse! (Check out link below for details.)

Please take a minute and watch the videos in the below links- definitely worth your time! Amazing what research can do!

http://www.uphs.upenn.edu/news/News_Releases/2013/12/ctl019/

http://on.aol.com/video/emily-whitehead-is-undergoing-an-experimental–leukemia-treatment-518050547

http://on.aol.com/video/emily-whitehead-is-undergoing-an-experimental–leukemia-treatment-518050547